There are 21 Category B Schools in Central Region. Below is the list of Category B Schools in the Central Region and their location region.
| NAME | GENDER | STATUS |
| Academy of Christ the King, Cape Coast |
Mixed | Day |
| Adankwaman Senior High | Mixed | D/B |
| Aggrey Mem. A.M.E.Zion SHS | Mixed | D/B |
| Apam Senior High | Mixed | D/B |
| Awutu Winton Senior High | Mixed | Day |
| Boa-Amponsem Senior High | Mixed | D/B |
| Breman Asikuma Senior High | Mixed | D/B |
| Diaso Senior High | Mixed | D/B |
| Edinaman Senior High | Mixed | D/B |
| Ekumfi T. I. Ahmadiiyya SHS | Mixed | D/B |
| Ghana National College | Mixed | D/B |
| Methodist High School, Saltpond |
Mixed | D/B |
| Mozano Senior High | Mixed | D/B |
| Nsaba Presby Senior High | Mixed | D/B |
| Nyakrom Senior High Tech | Mixed | D/B |
| Siddiq Senior High Sch. | Mixed | Day |
| Swedru Senior High | Mixed | D/B |
| Twifo Hemang SHTS | Mixed | D/B |
| Twifo Praso Senior High | Mixed | D/B |
| University Practice SHS | Mixed | D/B |
| Winneba Senior High | Mixed | D/B |
